FDA approves new targeted breast cancer drug

WASHINGTON (AP) — The Food and Drug Administration has approved a first-of-a-kind breast cancer medication that targets tumor cells while sparing healthy ones.

The drug Kadcyla from Roche combines the established drug Herceptin with a powerful chemotherapy drug and a third chemical linking the medicines together. The chemical keeps the cocktail intact until it binds to a cancer cell, delivering a potent dose of anti-tumor poison.

Cancer researchers say the drug is an important step forward because it delivers more medication while reducing the unpleasant side effects of chemotherapy.

"This antibody goes seeking out the tumor cells, gets internalized and then explodes them from within. So it's very kind and gentle on the patients — there's no hair loss, no nausea, no vomiting," said Dr. Melody Cobleigh of Rush University Medical Center. "It's a revolutionary way of treating cancer."

Cobleigh helped conduct the key studies of the drug at the Chicago facility.

The FDA approved the new treatment for about 20 percent of breast cancer patients with a form of the disease that is typically more aggressive and less responsive to hormone therapy. These patients have tumors that overproduce a protein known as HER-2. Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute.

The approval will help Roche's Genentech unit build on the blockbuster success of Herceptin, which has long dominated the breast cancer marketplace. The drug had sales of roughly $6 billion last year.

Genentech said Friday that Kadcyla will cost $9,800 per month, compared to $4,500 per month for regular Herceptin. The company estimates a full course of Kadcyla, about nine months of medicine, will cost $94,000.

FDA scientists said they approved the drug based on company studies showing Kadcyla delayed the progression of breast cancer by several months. Researchers reported last year that patients treated with the drug lived 9.6 months before death or the spread of their disease, compared with a little more than six months for patients treated with two other standard drugs, Tykerb and Xeloda.

Overall, patients taking Kadcyla lived about 2.6 years, compared with 2 years for patients taking the other drugs.

FDA specifically approved the drug for patients with advanced breast cancer who have already been treated with Herceptin and taxane, a widely used chemotherapy drug. Doctors are not required to follow FDA prescribing guidelines, and cancer researchers say the drug could have great potential in patients with earlier forms of breast cancer

Kadcyla will carry a boxed warning, the most severe type, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death. The drug can also cause severe birth defects and should not be used by pregnant women.

Kadcyla was developed by South San Francisco-based Genentech using drug-binding technology licensed from Waltham, Mass.-based ImmunoGen. The company developed the chemical that keeps the drug cocktail together and is scheduled to receive a $10.5 million payment from Genentech on the FDA decision. The company will also receive additional royalties on the drug's sales.

Shares of ImmunoGen Inc. rose 2 cents to $14.32 in afternoon trading. The stock has ttraded in a 52-wek range of $10.85 to $18.10.

Read More..

California lawmaker Rubio leaves Legislature for Chevron job

SACRAMENTO — State Sen. Michael J. Rubio, who was leading the Legislature's effort to make California's environmental laws more business-friendly, abruptly resigned from office Friday to accept a government-affairs job with Chevron Corp.

Rubio, a Democrat from Shafter, in the Central Valley, was chairman of the Senate Environmental Quality Committee and introduced bills during his two years in office that related to the oil industry in his district.

The state Fair Political Practices Commission will conduct a routine review of Rubio's move to make sure it involves no violation of the conflict-of-interest rules in California's Political Reform Act.

"We will look to see if there is something to indicate that the act was violated and, if so, we will take a look at it," said the commission's chief of enforcement, Gary Winuk.

Rubio said in an interview that he has complied with state law, and he declined to discuss the terms of his employment. He said he quit the Legislature because he had tired of the 300-mile drive from his district to the Capitol and has a special-needs daughter who requires attention.

"My family comes first," he said.

One of Rubio's bills would have clarified state codes to allow the practice of re-injecting natural gas as part of oil drilling. The 2011 measure, which stalled in a committee, was backed by the Western States Petroleum Assn., a group whose members include Chevron Corp.

In November, Rubio was among a group of legislators who went on a trip to Brazil that was paid for by the California Foundation on the Environment and the Economy, a nonprofit bankrolled by Chevron, PG&E and other firms. Sponsors sent representatives to accompany the lawmakers as they studied Brazil's low-carbon fuel standards and other issues.

In spearheading the push for streamlined environmental laws, Rubio worked closely with the Silicon Valley Leadership Group, whose members include Chevron Energy Solutions.

It is common for lawmakers to move into high-level jobs or consulting arrangements with interests that sought their help in shaping state policy. Rubio's announcement renewed complaints about the practice from watchdog groups.

Jamie Court, president of the advocacy group Consumer Watchdog, said the revolving door between the public and private sector always raises questions of whether politicians spend their time in office "auditioning for a well-paying job for the companies they are supposed to regulate."

Rubio's departure creates a third vacancy in the 40-person Senate that will temporarily put its Democrats' numbers below the supermajority they won in November.

Two Democrats had previously left for Congress, and special elections are being held in coming weeks for their seats. Both are widely expected to remain in Democratic hands, because the party has a comfortable registration advantage in those districts.

A special election will be called to fill Rubio's seat.

patrick.mcgreevy@latimes.com

Read More..

IHT Rendezvous: North Korea Widens Access to Internet, but Just for Visitors

HONG KONG — North Korea will finally allow people to search the Internet from their mobile devices and laptops within the country’s borders. But if you’re a North Korean, you’re out of luck — only foreigners will be given the privilege.

Cracking the door open ever so slightly to wider Internet use, the government has allowed a company called Koryolink to give foreigners access to 3G mobile Internet service by March 1, The Associated Press reported.

The decision, made public Friday, comes just a month after Google’s chairman, Eric E. Schmidt, visited Pyongyang and prodded officials on allowing Internet access, noting how easy it would be to set up through Koryolink’s expanding 3G network. Presumably, his appeal was directed at giving North Koreans such capability.

“As the world becomes increasingly connected, their decision to be virtually isolated is very much going to affect their physical world, their economic growth and so forth,” Mr. Schmidt told reporters after arriving at Beijing International Airport following his visit to North Korea. “We made that alternative very, very clear.”

Foreigners were only recently given access to cellphones while traveling in the country. Previously, they had to surrender their phones with customs agents.

Read More..

American Idol: Sudden-Death Round Begins for Men

TV Watch

By Steve Helling

02/21/2013 at 11:00 PM EST

From left: Randy Jackson, Mariah Carey, Ryan Seacrest, Nicki Minaj and Keith Urban

George Holz/FOX

On Wednesday, 10 women sang for five spots on American Idol's live shows. On Thursday, it was the remaining guys' turn.

The judges have their own euphemisms when they don't like a performance – it's usually easy to read between the lines: If they compliment a singer on his shoes, he won't advance. On Thursday, Nicki Minaj actually told a contestant, "Kudos to you for being really freshly, nicely groomed." They might as well have had a stagehand pull him offstage with an oversized vaudeville hook.

After several weeks of good behavior by the judges, Thursday's episode showed a spark of life when Nicki – who was wearing her very best Jan Brady wig – began rolling her eyes whenever Randy Jackson spoke. At one point, Ryan Seacrest even tried to get them to kiss and make up. There was talk about lipstick, and Mariah Carey did her best to look at anything other than the awkward air kiss that followed.

But the theatrics did not eclipsed some solid singers – and a few performances that just weren't good enough for the competition.

The Good: Curtis Finch Jr. wowed judges with his version of Luther Vandross's "Superstar." It was oversung. But there was no denying Finch's vocal talent. Charlie Askew's rendition of Elton John's "Rocketman" was interesting and well-suited to his voice. And Devin Velez pleased the crowd when he infused Spanish lyrics into Beyoncé's "Listen." The three of them advanced easily.

The Okay: Elijah Liu chose Bruno Mars's "Talking to the Moon," a song that felt current and new. Paul Jolley sang Keith Urban's "Tonight I'm Gonna Cry." Generally, it's a risky move to sing a song made popular by one of the judges, but Jolley's performance was pleasant, if a little shaky. Both advanced, although the judges were split on their assessment of Jolley.

The Others: Johnny Keiser, Kevin Harris, Chris Watson and Jimmy Smith sang unspectacular versions of various songs that everyone knows. Each of them had a decent voice, but none of their performances were all that unique, and none of them advanced. On the other side of the spectrum, J'DA performed an over-the-top rendition of Adele's "Rumor Has It." It wasn't enough for him to advance, but his performance – at one point he collapsed on the floor but continued singing – was by far the most memorable of the night.

There are ten contestants – five men and five women – who have made it to the next round. Next week, the remaining 20 contestants will complete for the remaining 10 spots – and all will hope the judges don't compliment what they're wearing.

Read More..

APNewsBreak: Govs to hear Oregon health care plan

SALEM, Ore. (AP) — Oregon Gov. John Kitzhaber will brief other state leaders this weekend on his plan to lower Medicaid costs, touting an overhaul that President Barack Obama highlighted in his State of the Union address for its potential to lower the deficit even as health care expenses climb.

The Oregon Democrat leaves for Washington, D.C., on Friday to pitch his plan that changes the way doctors and hospitals are paid and improves health care coordination for low income residents so that treatable medical problems don't grow in severity or expense.

Kitzhaber says his goal is to win over a handful of other governors from each party.

"I think the politics have been dialed down a couple of notches, and now people are willing to sit down and talk about how we can solve the problem" of rising health care costs, Kitzhaber told The Associated Press in a recent interview.

Kitzhaber introduced the plan in 2011 in the face of a severe state budget deficit, and he's been talking for two years about expanding the initiative beyond his state. Now, it seems he's found people ready to listen.

Hospital executives from Alabama visited Oregon last month to learn about the effort. And the U.S. Department of Health and Human Services announced Thursday that it's giving Oregon a $45 million grant to help spread the changes beyond the Medicaid population and share information with other states, making it one of only six states to earn a State Innovation Model grant.

Kitzhaber will address his counterparts at a meeting of the National Governors Association. His talk isn't scheduled on the official agenda, but a spokeswoman confirmed that Kitzhaber is expected to present.

"The governors love what they call stealing from one another — taking the good ideas and the successes of their colleagues and trying to figure out how to apply that in their home state," said Matt Salo, director of the National Association of Medicaid Directors.

There's been "huge interest" among other states in Oregon's health overhaul, Salo said, not because the concepts are brand new, but because the state managed to avoid pitfalls that often block health system changes.

Kitzhaber persuaded state lawmakers to redesign the system of delivering and paying for health care under Medicaid, creating incentives for providers to coordinate patient care and prevent avoidable emergency room visits. He has long complained that the current financial incentives encourage volume over quality, driving costs up without making people healthier.

Obama, in his State of the Union address this month, suggested that changes such as Oregon's could be part of a long-term strategy to lower the federal debt by reigning in the growing cost of federally funded health care.

"We'll bring down costs by changing the way our government pays for Medicare, because our medical bills shouldn't be based on the number of tests ordered or days spent in the hospital — they should be based on the quality of care that our seniors receive," Obama said.

The Obama administration has invested in the program, putting up $1.9 billion to keep Oregon's Medicaid program afloat over the next five years while providers make the transition to new business models and incorporate new staff and technology.

In exchange, though, the state has agreed to lower per-capita health care cost inflation by 2 percentage points without affecting quality.

The Medicaid system is unique in each state, and Kitzhaber isn't suggesting that other states should adopt Oregon's specific approach, said Mike Bonetto, Kitzhaber's health care policy adviser. Rather, he wants governors to buy into the broad concept that the delivery system and payment models need to change.

That's not a new theory. But Oregon has shown that under the right circumstances massive changes to deeply entrenched business models can gain wide support.

What Oregon can't yet show is proof the idea is working — that it's lowering costs without squeezing on the quality or availability of care. The state is just finishing compiling baseline data that will be used as a basis of comparison.

One factor driving the Obama administration's interest in Oregon's success is the president's health care overhaul. Under the Affordable Care Act, millions more Americans will join the Medicaid rolls after Jan. 1, and the health care system will have to be able to absorb the influx of patients in a logistically and financially sustainable way.

The federal government will pay 100 percent of the costs for those additional patients in the first three years before scaling back to 90 percent in 2020 and beyond.

"There are a lot of governors who are facing the same challenges we're facing in Oregon," Kitzhaber said. "They recognize that the cost of health care is something they're going to have to get their arms around."

Read More..

Garcetti and Greuel in duel for funds

Wendy Greuel and Eric Garcetti remain locked in a tight fundraising battle, with the front-runners in Los Angeles' mayoral contest each raising just under a half-million dollars in recent weeks and both showing ample cash reserves to wage a vigorous effort in the closing days of the primary campaign, according to disclosure reports filed with the City Ethics Commission on Thursday.

Greuel has a razor-blade edge — the city controller raised $473,582 and spent more than $1.7 million in the latest reporting period between Jan. 20 and Feb. 16. She enters the final days before the March 5 contest with nearly $1.7 million cash on hand, according to the reports.

Noting that nearly three-quarters of her recent contributions came from first-time donors and more than half were from contributors who gave $250 and under, Greuel said the figures signified the momentum behind her campaign.

"It's amazing that so many Angelenos from every corner of the city are coming together to join our grassroots campaign," Greuel said in a statement. "In this election, we can fight together to change our city. We can build a stronger economy that creates jobs, a seamless public transportation system and better schools. We can crack down on waste in government so Angelenos can get the services they deserve. Today's report shows that people across L.A. are joining together to make this vision a reality."

Greuel's main rival, City Councilman Garcetti, raised $452,819 and spent nearly $2.5 million during the same time frame, ending the filing period with $1.5 million cash on hand, according to campaign filings. He noted that with more than 10,000 donors, he leads the field in grassroots support.

"I'm proud that our campaign's momentum is growing every day as more people learn about my plans to create jobs and solve problems for L.A. residents," Garcetti said in a statement. "You can see our grassroots strength through our fundraising, our energized volunteer corps and our thriving online network."

Overall, fundraising by the mayoral candidates has topped $11 million. Greuel and Garcetti are saturating the television and radio airwaves and have started attacking one another in voters' mailboxes. They have been fairly even in their fundraising efforts for many months, allowing them both to run a robust advertising campaign. But while Garcetti spent more during the filing period, Greuel has a steep advantage in outside efforts on her behalf. Of the $1.7 million spent by independent committees, more than $1.2 million has been spent to boost her bid, largely by labor.

Voters typically only see the candidates' ads and mailers, or clips of them on the nightly news. Under the radar, the candidates are spending significant time raising the kind of money it takes to campaign in a city as sprawling as Los Angeles. On Wednesday night, Garcetti held a fundraiser at the Petersen Automotive Museum with some of the city's hottest chefs — turning out a young and stylish crowd who sampled craft beers and delicacies such as braised and crispy pork with salted oats, house mostarda and toasted broccoli. On the same night, Greuel held a fundraiser with U.S. Sen. Barbara Boxer (D-Calif.) at the Beverly Hills manse of billionaire media mogul Haim Saban. But unlike Garcetti, her campaign did not allow the media to attend.

Greuel's ads have highlighted her efforts as controller to root out "waste, fraud and abuse" — claims her opponents say she has exaggerated. On Thursday, Garcetti launched two new 15-second ads featuring his endorsement by the Los Angeles Times. Those followed two introductory spots in English and Spanish. The councilman is spending more than $600,000 this week airing ads, according to a Democratic media consultant who is not working for any candidate. Greuel and the efforts on her behalf, which are not allowed to legally coordinate with her campaign, spent about $1.3 million in the same period, according to the media consultant.

Councilwoman Jan Perry, who has been waging a blistering mail campaign against Greuel, continues to lag behind. She raised nearly $68,000 in the filing period, and spent nearly $809,000, leaving her with less than a half-million dollars for the remainder of the race. Emanuel Pleitez, the former technology executive who has never held elected office, reported raising nearly $20,000 and spending nearly $194,000 during the period, leaving him with nearly $146,000 cash on hand.

Kevin James, the sole Republican in the race, has been the beneficiary of nearly $500,000 in outside spending. He has had difficulties raising money, but his campaign has claimed that the numbers were improving. They did not file a disclosure report by press time, but his campaign manager said James had raised $52,000 and had spent $181,000 during the filing period, leaving the former entertainment attorney with about $25,000 cash on hand.

seema.mehta@latimes.com

maeve.reston@latimes.com

Times staff writer Maloy Moore contributed to this report.

Read More..

IHT Rendezvous: What of the Ringleaders, Chinese Ask About Cultural Revolution Case

BEIJING — It’s reminiscent, perhaps, of the trials of people accused of Nazi-era crimes, a John Demjanjuk, or a Samuel K.: in China this week, a man was tried for murdering a doctor during the Cultural Revolution, the China News Service reported.

A rare episode of justice for a neglected era? Judging by a discussion on China’s biggest microblog, Sina Weibo, ordinary people don’t necessarily see it just that way; rather, some are angry that a little guy, and not the masterminds of the violence, is being punished. What about the “ringleaders,” chief among them Mao Zedong, they are saying, often obliquely?

According to the report, which was widely disseminated online via news aggregators and other sites, the defendant at the rare trial this week, in Ruian in Zhejiang province, was a 80-plus-year-old man identified only as Mr. Qiu. He strangled a Mr. Hong with a rope in 1967, on the orders of a civilian militia, which suspected Mr. Hong of spying for a rival militia, the report said. Mr. Qiu had been on the run for decades and was arrested last July.

(For an English-language account, see this article in the South China Morning Post, which may be behind a paywall.)

After the killing Mr. Qiu cut off Mr. Hong’s lower legs with a shovel “to make it easier to bury him,” and then he buried him, the report said.

Violence was common during the era: yesterday, I examined this painful time in a Letter from China and Rendezvous post about Ping Fu, the businesswoman who wrote a controversial memoir.

As I wrote in my Letter, to this day, the state tightly controls discussion about the era – when many got away with, literally, murder.

“Have the main culprits who started the Cultural Revolution been punished?” asked a person with the handle Sansu dage, who added an angry red face to the posting.

“Actually, the biggest criminals of the Cultural Revolution have not been held responsible,” wrote a person with the handle Keji huangdan menwei chuangxin. “To pursue an ordinary criminal, decades later, is absurd.”

A_Jing wrote: “There should be mandatory courses in universities to talk clearly about the crimes against humanity during the Cultural Revolution!”

Wrote another: “All the cases from the Cultural Revolution should be tried.”

That’s extremely unlikely. A few key players were tried beginning in 1980, when Jiang Qing, Mao Zedong’s wife, and other members of the Gang of Four received lengthy sentences.

Yet, “I was Chairman Mao’s dog,” Ms. Jiang said in her defense. “Whomever he told me to bite, I bit.”

Read More..

American Idol: Women Face Sudden-Death Round

American Idol

By Jamie Bufalino

02/20/2013 at 11:00 PM EST

Mariah Carey

Mario Anzuoni/Reuters/Landov

American Idol threw yet another new twist at its 40 remaining contestants: a sudden-death round.

"One song, one chance, no mercy," Ryan Seacrest said as the first group of 10 female contestants gathered in Las Vegas to try to finally sing their way – in front of a boisterous studio audience – through to the "America votes" phase of the competition.

Five women moved on, five went home.

Kentucky high school junior Jenny Beth Willis, whose rendition of a Trisha Yearwood song earned mixed reviews from the judges, was the first up. Although Keith Urban appreciated her "effortless confidence," Nicki Minaj said her performance lacked excitement (a comment that elicited the first audience boos of the season). Final result: It was the end of the road for Willis.

Tenna Torres, 28, – who attended Mariah Carey's camp for kids as a youngster – took the stage next and impressed the judges with her take on the Natasha Bedingfield's "Soulmate." But she lost style points with Minaj, who didn't like one particular aspect of her look. "Lose the hair," said Minaj, who felt the contestant's coif aged her. Final result: She made it through to the Top 20.

The three most powerful performances of the night all made it to the next round: Nashville's Kree Harrison, who despite taking a decidedly plain-Jane approach to styling, wowed the judges with her version of Patty Griffin's "Up to the Mountain." "You sang the hell out of that song," said Carey.

Angela Miller, 18, of Massachusetts, belted out Jessie J's hit "Nobody's Perfect." But she pretty much was.

And Amber Holcomb, an assistant teacher from Texas, closed the show with a rousing (and well received) rendition of "My Funny Valentine."

For the final spot of the night, it came down to Anchorage, Alaska, resident Adriana Latonio, 17, who tackled Aretha Franklin's "Ain't No Way," and Shubha Vedula, a Michigan high school senior who sang Lady Gaga's "Born This Way."

Although the judges saw potential in both contestants, they ultimately picked Lantonio's powerhouse vocals in a final emotional moment.

Thursday will bring out the guys. The first round of 10 will take the stage to try to make the top 20 – but once again, five will go home.

Read More..

Doc groups issue list of overused tests, therapies

WASHINGTON (AP) — Don't be afraid to question your doctor and ask, "Do I really need that?"

That's the advice from leading medical groups who came up dozens of tests and treatments that physicians too often prescribe when they shouldn't.

No worrisome stroke signs? Then don't screen a healthy person for a clogged neck artery, the family physicians say. It could lead to risky surgery for a blockage too small to matter.

Don't routinely try heartburn medicine for infants with reflux, the pediatric hospitalists say. It hasn't been proven to work in babies, and could cause side effects.

Don't try feeding tubes in people with advanced dementia, say the hospice providers. Helping them eat is a better option.

These are examples of potentially needless care that not only can waste money and time, but sometimes can harm, says the warning being issued Thursday from medical specialty groups that represent more than 350,000 doctors.

Too many people "think that more is better, that more treatment, more testing somehow results in better health care," said Dr. Glen Stream, former president of the American Academy of Family Physicians, which contributed to the list. "That really is not true."

The recommendations are part of a coalition called Choosing Wisely, formed by the American Board of Internal Medicine Foundation. Participating medical societies were asked to identify five tests or treatments that are commonly overused in their specialty. The list is aimed at doctors and includes references to published studies. Consumers Reports and other consumer groups are publicizing the information in more patient-friendly terms.

Last year, the coalition listed 45 overused tests and treatments. It included some of the best known examples, such as too much imaging for back pain and repeating colonoscopies too frequently.

This year's list adds 90 more overused kinds of care. Some are the result of doctors' habits, hard to overcome despite new evidence, Stream said. Others come about because patients demand care they think they need.

Some other examples:

—Don't use opioid painkillers for migraines except as a last resort, say the neurologists. There are better, more migraine-specific drugs available without the addictive risk of narcotics. Plus, frequent use of opioids actually can worsen migraines, a concept known as rebound headache.

—Just because a pregnant woman misses her due date, don't race to induce labor if mom and baby are doing fine, say the obstetricians. Inducing before the cervix is ready often fails, leading to an unneeded C-section. "Just being due by the calendar doesn't mean your body says you're due," Stream notes.

—Don't automatically give a child a CT scan after a minor head injury, say the pediatricians. About half of children who go to the ER with head injuries get this radiation-heavy scan, and clinical observation first could help some who don't really need a CT avoid it.

—And don't leave an implanted heart-zapping defibrillator turned on when a patient is near death, say the hospice providers. This technology clearly saves lives by guarding against an irregular heartbeat. But if someone is dying of something else, or is in the terminal stages of heart disease, it can issue repeated painful shocks, to no avail. Yet fewer than 10 percent of hospices have formal policies on when to switch off the implants.

Read More..

Bulgari shows off Liz Taylor's gems

It isn't easy sometimes to be an ordinary person in Los Angeles, so near to and yet so far from the city's glamorous events.

You hear about the grand Oscar parties, but you will never be invited. The award ceremony may be taking place minutes from where you live, but you watch it at home, on TV, in your sweat pants — and you might as well be in Dubuque.

Rodeo Drive too can make you feel like a scrap on the cutting room floor. As you stroll the wide and immaculate sidewalks of Beverly Hills' iconic shopping street, you pass by boutiques you'd feel self-conscious walking into. In the windows are baubles and trinkets you could never in three lifetimes afford.

Which is why it is rather nice to be invited to make a private appointment at the house of Bulgari, the fine Italian jeweler that opened its doors in 1884.

Elizabeth Taylor loved Bulgari jewels. Richard Burton, whose torrid affair with her began during the filming of "Cleopatra" in Rome, accompanied her often to the flagship shop on the Via Condotti. He liked to joke that the name Bulgari was all the Italian she knew.

So it is fitting that starting Oscar week, the jeweler is celebrating the Oscar-winning star with an exhibit of eight of her most treasured Bulgari pieces.

They are heavy on diamonds and emeralds — of rare size, gleam and value.

And Bulgari knows their value well.

After Taylor's death, it reacquired some of the gems at a Christie's auction. One piece, an emerald-and-diamond brooch that also can be worn as a pendant, sold for $6,578,500 — breaking records both for sales price of an emerald and for emerald price per carat ($280,000).

That brooch, whose centerpiece is an octagonal step-cut emerald weighing 23.44 carats, was Burton's engagement present to Taylor. He followed it upon their marriage (his second, her fifth) with a matching necklace whose 16 Colombian emeralds weigh in at 60.5 carats. Bulgari bought the necklace back too, for $6,130,500.

They are in the exhibit, along with Burton's engagement ring to Taylor and a delicate brooch — given to her by husband No. 4, Eddie Fisher — whose emerald and diamond flowers were set en tremblant so that they gently fluttered as Taylor moved.

The jewels are not for sale.

On Tuesday night, actress Julianne Moore wore the Burton necklace, with pendant attached, at a gala for Bulgari's top clients. At the dinner hour, guests were escorted along a lavender-colored carpet to a nearby rooftop that had been transformed into a Roman terrace.

Those honored guests, of course, got private viewings of Taylor's jewels.

But so did Amanda Perry, a healer from West Hollywood who arrived the next morning for one of the first appointments available to the public.

Someone had emailed news of the collection to the 35-year-old Taylor fan. She walked in off the street Tuesday, when the exhibit was open only to press — and Sabina Pelli, Bulgari's glamorous executive vice president, fresh from Rome, was taking sips of San Pellegrino brought to her on a silver tray between back-to-back interviews that started at 5 a.m.

The camera crews were long gone when Perry came back Wednesday. She had the exhibit, and handsome sales associate Timothy Morzenti of Milan, entirely to herself.

In a black suit, still wearing on his left hand the black glove he dons to handle fine jewels, Morzenti whisked Perry off via a private elevator to the exhibit on the second floor. The jewels stood in vitrines mounted high off the ground. Behind them were photos and a slide show of Taylor, bejeweled.

"Which piece would you like to see first?" Morzenti asked her as a security guard stood by. "I personally love the emerald ring."

Then he proceeded at leisure to explain Bulgari-signature sugar-loaf cuts and trombino ring settings, while tossing in occasional Taylor stories.

Read More..